A Simple, Accurate and Precise method was developed and validated for the simultaneous determination of cefepime and tazobactam in injectable dosage form. Isocratic separation was achieved on YMC C18 column (250 × 4.6 mm, particle size 5 μm) using a mobile phase consisting of methanol-phosphate buffer (60:40 v/v) at a rate of 1 ml per minute and using ultra violet detector (230 nm). Linearity was observed over the concentration range of 12.5 to 37.5 μg/ ml (r2-0.99) for tazobactam and 100 to 300 μg/ml (r2-0.999) for cefepime. The % mean recovery of the method was 99% for tazobactam and 100% for cefepime. The limits of detection (LODs) were 0.149 and 1.2024 for tazobactam and cefepime and limits of quantification (LOQs) were 0.495 and 4.0080, respectively. The method was validated according to International Conference on Harmonization (ICH) Guidelines. The results of this method are proved that the method would have great value when used for the analysis of dosage form.