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Method validation of compleximetric titration for determination of iron in iron containing drugs
Author(s): Virab Kirakosyan, Andranik Davinyan
A simple and inexpensive titrimetric method was developed and validated according to International Conference on Harmonization (ICH) and United State Pharmacopoeia (USP). The method is based on complex formation between ferric (Fe3+) ions and disodium edetate (EDTA) in strong acidic media.The endpoint of titration was determined visually. Sulfosalicylic acid was used as an indicator (color change: from dark pink to light yellow at pH = 2). The method was validated regarding to linearity, precision and accuracy, giving good results.