The liver is an important organ for maintenance of body general function and homeostasis. In addition to its role in the digestive process, it is important to detoxify unwanted substances. There are many varieties of drugs and chemicals are used to shows a toxic effect on liver e.g. ccl4, Peracetamol, Glactosamine, Methotrexate and many more at different dose. In this review we are going to discuss the toxic dose of methotrexate causes hepatotoxicity. Methotrexate (Mtx) is a antagonist of folic acid and also a cytotoxic agent that is responsible to inhibit cellular growth. It is used in many clinical symptoms i.eleukemia, lymphomas etc. The present overview summarizes some of the basic concepts involved in hepatotoxicity, their preclinical evaluation methods and some hepatotoxic models based upon dose.
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