Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Microwave assisted a novel synthesis for new substituted imidazoles

Author(s): Syed Sultan Qasim, Syed Shahed Ali

The three component synthesis of 2- phenylimidazo [4,5-f] [1,10] Phenanthroline derivatives, a typical acid catalyzed reaction, could be conducted successfully with good to excellent yields in a neutral ionic liquid, 1-methyl-3-heptyl-imidazolium tetrafluoroborate [(HeMIM) BF4], under solvent free and microwave assisted conditions. The combined merits of microwave irradiation and ionic liquid make the three-component condensation with safe operation, low pollution, rapid access to products and simple workup


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