Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Microwave assisted catalyst free synthesis of 3-hydroxy-2-oxidoles by aldol condensation of acetophenones with isatins

Author(s): H. M. Meshram, N. Nageswara Rao, N. Satish Kumar, L. Chandrasekhara Rao

An efficient and catalyst free method is described for the synthesis of oxindole by the reaction of isatin with ketones under microwave irradiation. The method is applicable for a variety of isatins and ketones and avoids the use of organic solvent. Some new oxindoles are prepared in good yield.


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