Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Microwave Assisted Synthesis and Evaluation for Anticonvulsant Activity of Some 1,4 Dihydropyridine Derivatives

Author(s): Dinesh Rishipathak, Luketa Alai, Kanchan Somase, Sanjay Kshirsagar

Several new promising bioactive derivatives of 3,3’-(2, 6-dimethyl-4-substituted aryl-1, 4-dihydropyridine-3,5-diyl)-bis-(N-benzylidene-1H-1,2,4-triazol-5-amine) were synthesized under microwave irradiations. The compounds were obtained in excellent yields. All the titled compounds were characterized by Infrared Radiation (IR), Proton Nuclear Magnetic Resonance (1H-NMR), and mass spectral analysis. Synthesized compounds were evaluated for their anticonvulsant effect using PTZ induced convulsion studies. The pharmacological evaluation of the compounds showed increase in latency (onset time) to induce convulsions; decrease in the number of convulsions and increase in latency of death compared to control. The compounds A-I and I-II showed highest percentage of protection (80%) at the dose of 20 mg/kg among the evaluated compounds compared to control. The analysis of structural features revealed that substitution of Chloro group and methoxy group enhanced the anticonvulsant potential of the synthesized compounds.

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