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Microwave assisted synthesis of triazolothiadiazole analogues as anticancer and antibacterial agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Microwave assisted synthesis of triazolothiadiazole analogues as anticancer and antibacterial agents

Author(s): G. C. Ramaprasad, Balakrishna Kalluraya, B. Sunil Kumar, Sahana Mallya

A series of 3-(5'-fluoro-2'-methoxybiphenyl-3-yl)-6-(substituted)[1,2,4]-triazolo[3,4-b][1,3,4]-thiadiazole (3a-j) were synthesized by conventional and microwave irradiation methods. Microwave method proved to be a rapid and better yield compare to that of conventional method. The structures of these compounds were established on the basis of spectral and analytical data. These novel compounds were screened for their antibacterial and anticancer activity. The promising compounds 3b and 3g have been identified.


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