Some common molecules like antipyrine and toluene-p-sulphonamide have been synthesized by Microwave Assisted method i.e. “Green Synthesis”. The reaction yields were compared with reported conventional method. The purpose of this study was increasing practical yield, lowering the reaction time and reducing pollution. The products were characterized by various techniques like melting point, Thin Layer Chromatography (TLC), partition coefficients, dissociation constants, % ionization, Fourier Transform Infrared (FTIR) spectroscopy, Mass and Proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy.