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Microwave assisted synthesis, physicochemical properties and antimicrobial activity of benzimidazole chalcones | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Microwave assisted synthesis, physicochemical properties and antimicrobial activity of benzimidazole chalcones

Author(s): Bijo Mathew, Unnikirishnan.G., Shafeer. V.P., Mohammed Musthafa.C., Femina.P.

The objective of our research was to perform some benzimidazole chalcone moieties via an efficient method of microwave assisted and correlated their antimicrobial activity with CLogP value determined by ChemDraw Ultra 11.0 software. The structures of the final candidates were confirmed by spectral studies. All the synthetic derivatives were evaluated for their antimicrobial studies .Most of the derivatives were good activity towards Gram-positive bacteria and less activity towards Gram-negative bacteria. Some of the derivatives showed a moderate activity against tested fungi. SAR of the final candidates revealed a correlation between ClogP and antimicrobial studies. It has been concluded that higher logP value favours the activity ratio.


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