Microwave Assisted-Solvent Free Synthesis of Imidazo[1,2-a]pyridines | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X


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Microwave Assisted-Solvent Free Synthesis of Imidazo[1,2-a]pyridines

Author(s): Tejeswararao Dharmana, Mallika Swapna

A facile microwave assisted reaction of phenacyl bromide and 2-amino pyridine is catalyzed by an ionic liquid 1-(4-sulfonic acid) butylpyridinium hydrogen sulfate under solvent free conditions to give corresponding imidazo[1,2-a]pyridines in good yields. Reactions proceed with high efficiency and good functional group tolerance. This approach provides a useful protocol for the preparation of highly substituted imidazo[1,2-a]pyridine derivatives.


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