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An efficient synthesis of Novel pyrrolederivatives was achieved via solventless reaction of chalcones 1(a-e) with different aldehydes 2(a-e) and ammonium acetate in the presence of sodium cyanide in one-pot under microwave irradiation. The notable features are short reaction time, high yield and purification of product by non-chromatographic methods, i.e., by simple recrystalization compared to the classical condition. Some of the synthesized compounds were evaluated against HepG-2, and showed significant antitumor activities.