Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Microwave-Assisted One-Pot Synthesis of Novel Polyarylpyrrole Derivatives of Expected Anticancer Activity

Author(s): Ahmed Younis, Ali M Hassan, Mohamed F Mady, El-Haddad AF, YassinFA, Mahmoud Fayad

An efficient synthesis of Novel pyrrolederivatives was achieved via solventless reaction of chalcones 1(a-e) with different aldehydes 2(a-e) and ammonium acetate in the presence of sodium cyanide in one-pot under microwave irradiation. The notable features are short reaction time, high yield and purification of product by non-chromatographic methods, i.e., by simple recrystalization compared to the classical condition. Some of the synthesized compounds were evaluated against HepG-2, and showed significant antitumor activities.


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