Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Molecular interaction study of aqueous solution of an aminoglycoside antibiotic Neomycin at 298.15 to 308.15 K

Author(s): K. C. Patil and C. M. Dudhe

Ultrasonic velocity, density, and viscosity of aqueous solutions of aminoglycoside antibiotic- Neomycin sulphate at three different temperatures 298.15, 303.15 and 308.15K, for various concentrations (0.0010 - 0.1003) have been measured. From the experimental data, important acoustic parameters such as acoustic impedance, adiabatic compressibility, free length, relaxation time, internal pressure, absorption coefficient, free volume, Rao’s constant, Wada’s constant, cohesive energy, Gibb’s free energy, relative association and Van der Waal’s constant were calculated. These parameters were used to study the molecular interactions in aqueous neomycin solutions. It was observed that the classical absorption and relaxation time decreases with the rise in temperature, due to weakening of intermolecular hydrogen bondings.