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Mycobacterial CYP121 as a target for anti-TB drug discovery | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Mycobacterial CYP121 as a target for anti-TB drug discovery

Author(s): Hend A. A. Abd El-wahab, Ahmed S. Aboraia, Hamdy M. Abdel-Rahman, Mahmoud A. El-Gendy and Claire Simons

Despite the introduction of the first line treatment regimen forty years ago and the continuous trials since that time to introduce new regimens, tuberculosis (TB) is considered to be the cause of considerable mortality worldwide. Recent research highlighted the Mycobacterium tuberculosis (Mtb)CYP450s as potential drug targets. This article reviews mycobacterial CYP121 as a target for anti-TB drug discovery


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