Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

N-alkylation of azoles disubstituted acetamides under microwave and Mannich reaction conditions

Author(s): Ambarsing P. Rajput and Rambhau P. Gore

The N-alkylation of some secondary amides, 2-(1H-azol-1-yl)-N-(substituted phenyl) acetamides, was carried out under different conditions basic, microwave and Mannich reaction. The attempts of alkylation of secondary amides using strong bases were unsuccessful. These prompted us to apply microwave and Mannich reaction.


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