The current study was undertaken to elucidate a possible neuroprotective role of myrtle and ginger against lipopolysaccharides(LPS ) induced neurotoxicity in experimental rat model. Ginger (Zingbar officinale)and myrtle((Myrtus communis )was administered orally (1 gand 300 mg /kg b.wt respectively for one month then neurotoxicity was produced in male rats by intraperitoneal injection of 200ug/g b.wt. After such treatment(4 hr after LPS injection ), the animals were sacrificed and analyzed for oxidative stress biomarkers, such as, nitric oxide (NO) and malondialdehyde,(MDA), interleukine-1β (IL-1β),Tumour necrosis factor α (TNF-α) ,estrogen , 5LOX .15LOX ,lipoxin A4( LA4), Asymmetric dimethyl arginine (ADMA) and Willebrand factor( VWF)were determined in serum and brain tissue of challenged rats. The results revealed significant increase in all investigate stress parameters associated with significant decrease in the estrogen level inLPS-intoxicated rats. Marked amelioration was detected in all biomarkers under investigation upon treatment of LPS induced neurotoxic rats with myrtle or ginger with more or less similar ameliorative effects .