Abstract

Neuroprotective Effects of VEM-PD Nasal drops against MPTP- Induced Parkinsonâ??s Disease in Mice

Author(s): Muralidhar S Talkad*, Aamir Javed, Niranjan Koirala, Vijay Satish and Anil Kumar HV

Objective: VEM-PD nasal drops are made of a proprietary herbal blend with micro-emulsions and CNS & PD-beneficial Bio-Actives. Which looked into the potential protective mechanisms of VEM- PD Nasal drops on a mouse model of Parkinson's disease (PD) caused by 1-methyl-4- phenyl- 1,2,3,6-tetrahydropyridine (MPTP). Methods: PD Nasal Drops dose levels that are specific on the levels of glutathione and malondialdehyde in the brain, as well as the activities of antioxidant enzymes in the striatum, extracts of 2 drops twice and 2 drops three times each were administered orally for 15 days in a row until behavioral observations were made. Results: MPTP (20 mg/kg, ip) was administered twice daily for five days prior to behavioral observation. When combined with MPTP + VEM-PD 2 drops /3 times, the striatum's glutathione (GSH) levels and antioxidant enzyme activity returned to nearly normal levels in the MPTP-induced group (1.33 0.06). In the MPTP-induced group 8.11 0.05, treatment group 2.63 0.143 reduced the increased levels of malondialdehyde (MDA) in mice to close to normal in the MPTP + VEM-PD 2 drops /3 times, striatum. 4.45 0.169 for the treated group. In the High Dose 2 drops (extracts) /3 times treated mice, histopathological analysis of the hippocampus region of the brain demonstrated a considerable reduction in MPTP-induced severity and a return of the brain's histological architecture to nearly normal morphology. Conclusion: Overall, our research indicated that VEM-PD Nasal drops have neuroprotective qualities and may be a useful treatment for Parkinson's disease.

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