New Potential Antitumor Nitrogen Heterocycles: Synthesis and Cytotoxic Evaluation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


New Potential Antitumor Nitrogen Heterocycles: Synthesis and Cytotoxic Evaluation

Author(s): Elsherbiny H. Elsayed and Eman M. Radwan

A new 2-(p-nitrobenzylidene)-4-phenyl-5-oxo(thioxo)-1,2,4-triazino-[2,1-a]-1,2,4-triazine-1,7-diones (2a,b) and 2- (5-phenylthiazol-2-yl)-3-phenyl-5-(p-nitrobenzylidene)-1,2,4-triazine-6-one (5) were prepared via cyclocondensation of 2-substituted-1,2,4-triazine (1a,b) with ethyl chloroacetate and phenacyl bromide in presence of fused sodium acetate. Alkylation of compounds 2a,b with ethyl chloroacetate in dimethyl formamide yielded Nalkylated products (3a,b). Condensation of compound 2a with aromatic aldehydes afforded the corresponding arylidene derivatives (4a,b). N-acetyl derivative (6) was obtained via acetylation of compound 5 with acetic anhydride. The structures of the compounds were elucidated by using spectral and elemental analysis. All the prepared fused triazino- and thiazolyl-1,2,4-triazine were evaluated for their cytotoxicity against HepG-2 cell line. Some of newly synthesized 1,2,4-triazine derivatives emerged as a potential candidate for the development of future cytotoxic compounds.


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry