Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Newer RP-HPLC Method Development and Validation for the Simultaneous Estimation of Telmisartan and Amlodipine in Dosage Form
Author(s): Madhuri*Reverse-phase high-performance liquid chromatography (RP-HPLC) has become a cornerstone analytical tool for the quantitative determination of multiple active pharmaceutical ingredients (APIs) within a single dosage form. Telmisartan and Amlodipine-an angiotensin II receptor blocker and a calcium-channel blocker, respectively-are often combined in fixed-dose formulations to enhance antihypertensive efficacy. This review consolidates theoretical concepts, method-development strategies, and validation protocols in accordance with ICH Q2 (R1) guidelines. It further surveys the literature from 2015 to 2024, highlighting innovations such as rapid and eco-friendly RP-HPLC approaches. The newly developed methods exhibit superior resolution, precision, and robustness, confirming RP-HPLC as the technique of choice for simultaneous estimation of Telmisartan and Amlodipine in pharmaceutical dosage forms.
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