Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Non-genotoxic and Eco-friendly Synthesis of Chalcones Using Alum (KAI SO4)2.12H2O) as an Efficient and Novel Catalyst

Author(s): Ansar R Shaikh, Chishty SQ, Mazhar Farooqui, Syed Abed

We report a new environmentally-benign, convenient and facile methodology for the synthesis of non-genotoxic Chalcones using Alum (KAI (SO4)2.12H2O) as catalyst. The reaction of 2-hydroxy acetophenone with aldehydes in aqueous ethanol at ambient temperature has been studied. The reaction has yielded chalcones in one step. Furthermore, a series of compounds were synthesized and characterized by melting point, Electron Ionization-Mass Spectrometry (EI-MS), Nuclear Magnetic Resonance (NMR) and Infra-Red (IR) tools. The formation of desired product was confirmed by comparing them with reference compounds. Utilization of aqueous medium, easy reaction conditions, isolation and purification makes this manipulation very interesting from an environmental and economic perspective. Synthesized chalcones are non-genotoxic compounds as there is no functional group those are known as a genotoxic as (1) Aromatic compounds such as N-hydroxyaryls, N-acelated aminoaryls, Az-aryl-N-oxides and amino aryls, (2) Alkyl and aryl groups: N-methylols, N-antirasoamines, carbamates, nitro compounds, (3) Heteroaromatic groups such as Michel reactive acceptors, alkyl ester of phosphonates, sulphonates, halo-alkenes, halo-alkanes.