Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Novel dihydropyrimidine derivatives as antibacterial agents

Author(s): Nevagi Reshma J, Narkhede Harsha I

Novel dihydropyrimidine derivatives were synthesized and evaluated for antibacterial activity against Gram positive and negative bacterias. In the present study, synthesis involves the modification of dihydropyrimidine (DHPM) pharmacophore with thiosemicarbazide, semicarbazide functions. All the newly synthesized compounds were characterized by their spectral data and further used to estimate their ability towards antibacterial activity. Antibacterial activity was carried out by serial dilution method using Streptomycin as standard drug. Compound - (4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide (6C) showed comparable activity with the standard used.