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Novel indole-3-carboxaldehyde analogues: Synthesis and their antioxidant evaluation | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Novel indole-3-carboxaldehyde analogues: Synthesis and their antioxidant evaluation

Author(s): Nagaraja Naik, H. Vijay Kumar, N. M. Roopashree

A series of novel indole-3-carboxaldehyde conjugated with different aryl amines were synthesized and examined for their antioxidant potential to probe the most potent analogues using two in vitro models like 2,2-diphenyl-1- picrylhydrazyl (DPPH) free radical scavenging assay and inhibition of microsomal lipid peroxidation (LPO) assay. Through the compounds showed various degree of activity whereas, compound (5f) displayed superior antioxidant activity relative to other examined analogues and also exhibit more activity than the standard, butylated hydroxy anisole (BHA).


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