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Novel method for the synthesis of substituted tetrahydrocarbazoles using aqueous sulphuric acid | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Novel method for the synthesis of substituted tetrahydrocarbazoles using aqueous sulphuric acid

Author(s): Yedukondalu M, Sridhar R and M. V. Basaveswara Rao

An efficient and high yielding process has been developed for the synthesis of 6-substituted 3-hydroxy tetrahydrocarbazoles by reacting in situ generated cyclohexanones from the corresponding protected ketals with substituted hydrazine hydrochlorides in the presence of dil. Sulfuric acid. A small library of fourteen compounds has been made with 92-97% yields to check the generality of the reaction.


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