Trientine has been tested for inhibition of the spontaneous development of hepatitis and hepatic tumours in rats. It has been described in the use of copper binding compounds in the treatment of various disorders, including treatment of diabetes mellitus and complications thereof, including diabetic cardiomyopathy. We hereby wish to report first synthesis of Impurities A, B, C, D, E, G and H along with Impurity F via innovative approach starting from cheap raw materials.
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