Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Novel Spectrophotometric method for estimation of Ranolazine in bulk and pharmaceutical dosage forms

Author(s): Jagdish Bidada, Indrajit Gonjari, Chandrakant Raut, Chetan Bhutada

A simple and rapid UV-spectrophotometer estimation method for the evaluation of ranolazine is used in management of chronic angina has been developed and assessed. The proposed methods were successfully applied for the estimation of ranolazine in commercial pharmaceutical preparation and in bulk formulation with UV detection at 272 nm. A Shimadzu 1700 U.V visible spectrophotometer with 1cm matched quartz cells, and methanol: water solvent was employed in the method. Developed methods obeyed the Beer’s law in the concentration range of 10-100 μg/ml. methods were validated statistically. The SD and RSD of that was found satisfactorily low. Percentage recovery of the drug for the proposed method ranged from 99.345-100.43% indicating no interference of the tablet excipients. The results of the tablet analysis were validated with respect to accuracy (recovery), linearity, limit of detection and limit of quantitation were found to be satisfactory.


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