Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Novel spectrophotometric method for the estimation of Nisoldipine in bulk and pharmaceutical dosage forms

Author(s): Mohammed M. Safhi

A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of nisoldipine in bulk and in pharmaceutical formulations. Nisoldipine exhibits absorption maxima at 237 nm. Developed method obeyed the Beer’s law in the concentration range of 4 - 40 μg/mL. The method is accurate, precise and economical. The proposed method has been applied successfully for the analysis of the drug in pure and in its tablet dosage forms. In this method, there is no interference from any common pharmaceutical additives and diluents. The % recovery is greater than 99.86 – 100.67%, this shows that the method was free from the interference of excepients. The results of the tablet analysis were validated with respect to accuracy (recovery), linearity, limit of detection and limit of quantization were found to be satisfactory.


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