Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Novel Ultra High Performance Liquid Chromatographic Study for Simultaneous Determination of Canagliflozin and Metformin in Binary Mixtures

Author(s): Wafaa A Zaghary, Shereen Mowaka, Moataz S Hendy

An easy, accurate, and decisive UHPLC chromatography method for determination of both Metformin (MET) HCl and Canagliflozin (CANA) together either in bulk, binary mixtures or in dosage form has been developed and validated. Analysis was operated on Symmetry® Acclaim™ RSLC 120 C18 column (100 mm, 2.1 mm, 2.2 μm) whose temperature was maintained at 60°C. Meanwhile mobile phase was potassium dihydrogen phosphate buffer pH (3.5)-acetonitrile (45:55, v/v) at flow rate of 0.4 ml.min-1. UV detection was carried out at 225 nm. Linearity, accuracy and precision were adequate and solid over 0.5-90 μ for Metformin hydrochloride and 1-50 μ for canagliflozin hemihydrate as concentration ranges for each. This method was employed productively in analysis of laboratory mixtures besides their combined brand dosage form. Statistical comparison with reported technique gives no significant divergence in veracity and precision. The directness and sensitivity of the method empower its use in day-to-day quality control experiments.

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