Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


One Pot Multi Component Synthesis of Novel Dihydropyridine Derivatives

Author(s): Nooka Ratnam Appna, Korupolu Raghu babu, Srividhya Maripi, Srinivas Garaga

The one pot synthesis of dihydropyridine derivatives (1a-e) were synthesized in good yields by the Hantzsch reaction of different aryl hetero cyclic aldehydes (2a-e) with acetoacetic ester 3 and ammonium acetate 4 in presence of organocatalysts, guanidine hydrochloride. The present work describes the synthesis and characterization of novel dihydropyridine derivatives (1a-e) first time with spectral data (1H-NMR, 13C-NMR, IR and MS).