Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


One-pot three-component synthesis of pyrimidine-5-carbonitrile derivatives in water using p-dodecylbenzenesulfonic acid as catalyst and evaluation of in vitro anti-inflammatory and anthelmintic activities.

Author(s): Bharatkumar M. Sapkal and Dhananjay H. More

The present paper deals with the synthesis of Pyrimidine-5-carbonitriles by condensation of aromatic aldehydes, pchlorobenzoylacetonitrile and substituted urea using Conc. H2SO4 in ethanol and DBSA (p-dodecylbenezenesulfonic acid) in water as catalyst. It was observed that use of DBSA as catalyst increased the rate of reaction. The products are formed in high yields under eco-friendly conditions. All newly synthesized compounds were characterized by IR, 1H NMR and 13C NMR spectral data. Compounds (4a-k) were screened for anthelmintic activity and antiinflammatory.


SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan