The present paper deals with the synthesis of Pyrimidine-5-carbonitriles by condensation of aromatic aldehydes, pchlorobenzoylacetonitrile and substituted urea using Conc. H2SO4 in ethanol and DBSA (p-dodecylbenezenesulfonic acid) in water as catalyst. It was observed that use of DBSA as catalyst increased the rate of reaction. The products are formed in high yields under eco-friendly conditions. All newly synthesized compounds were characterized by IR, 1H NMR and 13C NMR spectral data. Compounds (4a-k) were screened for anthelmintic activity and antiinflammatory.