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One-pot three-component synthesis of pyrimidine-5-carbonitrile derivatives in water using p-dodecylbenzenesulfonic acid as catalyst and evaluation of in vitro anti-inflammatory and anthelmintic activities. | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

One-pot three-component synthesis of pyrimidine-5-carbonitrile derivatives in water using p-dodecylbenzenesulfonic acid as catalyst and evaluation of in vitro anti-inflammatory and anthelmintic activities.

Author(s): Bharatkumar M. Sapkal and Dhananjay H. More

The present paper deals with the synthesis of Pyrimidine-5-carbonitriles by condensation of aromatic aldehydes, pchlorobenzoylacetonitrile and substituted urea using Conc. H2SO4 in ethanol and DBSA (p-dodecylbenezenesulfonic acid) in water as catalyst. It was observed that use of DBSA as catalyst increased the rate of reaction. The products are formed in high yields under eco-friendly conditions. All newly synthesized compounds were characterized by IR, 1H NMR and 13C NMR spectral data. Compounds (4a-k) were screened for anthelmintic activity and antiinflammatory.


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