Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Optimization of an in vitro release test for topical formulations containing eberconazole nitrate and mometasone furoate

Author(s): P. B. Modi and N. J. Shah

A simple and reproducible in vitro release test (IVRT) method is developed for the performance evaluation of topical formulations containing Eberconazole nitrate and Mometasone furoate by using Franz Diffusion Cell. The method utilized polysulfone membrane and 1% Sodium lauryl sulfate with ethanol as receptor media that suffice sink condition. The method is able to discriminate release profile of Eberconazole nitrate and Mometasone furoate from market formulations having different viscosities. This method can be utilized in pharmaceutical industries for monitoring of batch to batch reproducibility, discriminate formulations with respect to change in process and formulation composition and for comparative IVRT study of generic formulations to build confidence prior to costly clinical study.


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