The ability of cuttlefish shell (Sepia recurvirostra) to adsorb heavy metals copper in water solutionhave been investigated. The study was conducted in laboratory scale using batch method and using synthetic waste of Cu. Optimum biosorption conditions determined of pH, adsorbent dosage, the initial concentration of metal ions, contact time and temperature. The results showed the highest Cu ion biosorption capacity in synthetic waste of Cu(II) amounted to 29.535 mg/g at pH 4; biosorbent dose of 0.2 g; initial concentration of Cu(II) 140 mg/L and the contact time of 1 hour. Biosorption equilibrium described with Freundlich Isotherm equation and biosorption kinetics known to follow the pseudo second order with a value of R2 each 0.9483 and 0.9999. Biosorption thermodynamic parameters are determined by the free energy change (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) during biosorption at a temperature of 29-400C.