Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Optimization of Imidazole Ring Formation Reaction Using DOE-Central Composite Design

Author(s): Tonmoy Chitta Das, Syed Aziz Imam Quadri, Mazahar Farooqui

Phenyl imidazole propionate derivative which shows wide range of biological activities was synthesized. The yield of imidazole ring formation i.e. conversion of 1-isopropyl 3-(2-oxo-2-phenylethyl)2-(4-methoxybenzyl)malonate (1) to tert-butyl 3-(4-methoxyphenyl)-2-(4-phenyl-1H-imidazole- 2-yl)propanoate (2) was improved from 35% to 87%. Statistical model based screening and optimization DOE study were carried out to derive the most favorable design space and optimal operating condition for the process parameters. The model of optimization study was created using central composite design. Model-validation was performed which showed excellent reproducibility with high degree of precession. Use of ammonium chloride as a catalyst to improve the yield of imidazole ring formation reaction was also explored for the first time.

image


Full-Text PDF

FIND ARTICLES
SCImago Journal & Country Rank
Recommended Conferences
bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan