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Optimization of solid phase synthesis of quinazolin-4-ones | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Optimization of solid phase synthesis of quinazolin-4-ones

Author(s): Robert Musiol, Mieczyslaw Sajewicz

Optimization of microwave assisted solid phase synthesis of quinazolin-4-ones was discussed in this paper. Two step synthesis yielded in 2-methyl-4H-3,1-beznoxazin-4-one and quinazolin-4- one was optimized in microwave conditions. Different solid supports as well as reaction time, amount of support and temperature were optimized by means of design of experiment approach. We were able to obtain the product with 80% overall yield and with good purity above 95% Resulted terms of synthesis were applied in synthesis of biologically active styrylquinazolines.


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