Thiazolidinone, a saturated form of thiazole with carbonyl group on fourth carbon, has been considered as a magic moiety which posses almost all types of biological activities. It belongs to an important group of heterocyclic compounds containing sulfur and nitrogen in a five member ring. There are a large number of heterocyclic five membered rings are available but thiazolidinone posses a large number of biological activity. It has been found that moiety exhibits remarkable activity against human immunodeficiency viruses type 1 reverse transcriptase inhibitors. In literature survey it has been found that in combination with many group of heterocyclic ring the spectrum of pharmacological activity associated with thiazolidinone and its derivatives can be broden. Present review deals with all the pharmacological activities related with thiazolidinone along with future aspects.