Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Phenolic compounds from the stem bark of Erythrina orientalis and their cytotoxic and antioxidant activities
Author(s): Tjitjik Srie Tjahjandarie and Mulyadi TanjungTwo prenylated pterocarpans, phaseollin (1), shinpterocarpin (2) together with flavonoids, 4’-O-methyl licoflavanone (3), alpinumisoflavone (4), 8-prenyl-daidzein (5), have been isolated from the stem bark of Erythrina orientalis. The structures of these compounds were determined based on UV, IR, HRESIMS, 1D and 2D NMR data. Compounds 1–5 were evaluated for their cytotoxic properties against P-388 cells, their IC50 values 2.55, 2.43, 17.98, 4.31, and 5.82 μg/mL, respectively. Compounds 1, and 5 exhibited very high antioxidant activity against DPPH radical scavenging.
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Citations : 25868
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