Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Phenylboronic acid-catalyzed a four component synth esis of pyrano[2,3-c] pyrazole derivatives in aqueous media: an eco-frien dly method

Author(s): Amine Khodja Imène, Ghalem Wassima, Boulcina Raouf, Boumoud Taous and Debache Abdelmadjid

An efficient and eco-friendly one-pot synthesis of 6-amino-3-methyl-4-phenyl-2,4-dihydropyrano[2,3-c]p yrazole-5- carbonitrile derivatives by four-component phenylb oronic acid-catalysed reactions of aryl aldehydes , malononitrile, ethyl acetoacetate and hydrazine hyd rate in aqueous media is described. This method pro vides several advantages such as shorter reaction times, excellent yields, and a simple workup procedure.


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