A series of Schiff base derivatives has been synthesized by reaction between aromatic aldehydes and various aromatic by conventional and microwave assisted method. The structures of the compounds have been confirmed by IR and 1HNMR spectroscopy. The pka value and partion coefficient of the compounds have shown that compounds are acidic and lipophillic in nature. From biological investigation it was found that all the compounds have been shown potent antimicrobial, CNS depressant and analgesic activitie compare to standards.
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