The aim of present study was to screen the physicochemical and phytochemicals of hydroalcoholic extract of various herbal drugs like Cajanas cajan, Curcuma longa, Piper nigrum, Glycyrrhiza glabra, Coriandrum sativum, Withania somnifera with anticancer activity. Considering the importance of the above mentioned plants an attempt is made to study the preliminary physicochemical and phytochemical screening. The study includes preparation of extract by cold maceration process for detailed analysis. Different physicochemical parameters like ash value (total ash and acid insoluble ash), loss on drying and phytochemical parameters such as extractive value (alcohol soluble and water soluble) are carried out as per recommended procedures. The phytochemical determinations revealed that all the selected plants contain alkaloids, flavanoids, tannins and glycosides.