Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Platelet aggregation inhibition potential of some novel piperidino thiophenes analogs

Author(s): Sajal Srivastava and Barnali Das

In an attempt to explore antiplatelet inhibitory potential of newly synthesized compounds, a series of fused thiophene containing Schiff base moiety were prepared via the reaction of ketone, 4-N-methyl piperidone with the isobutylcyanoacetamide using ammonium acetate/glacial acetic acid as an acidic catalyst followed by reaction of starting compounds with substituted aryl aldehydes under microwave radiation. The synthesized compounds were screened for in-vitro anti-platelet aggregation activity by GVR Born method. The results clearly revealed that all these piperidinothiophenes contains anti-platelet aggregation activity when compared with the standard Heparin.


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