The outer rinds or peels of many fruits are not eaten and are thrown as a waste. Similarly in food industry, processing of fruits results in the formation of agro waste in high amounts and is common in the form of peels. This waste has to be managed efficiently as they pose serious problems to environment. Till now agro waste is used as livestock feed or as fertilizer but recently strategies have been developed to explore the bioactive components from the peels as well as their therapeutic benefits. Many scientific investigations reported the isolation of constituents with promising antioxidant, antimicrobial, antiproliferative activities from the peels of various fruits.