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Potential Protective effect of Vitamin C on Cerebral Ischaemia Reperfusion Injury in Rats | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Potential Protective effect of Vitamin C on Cerebral Ischaemia Reperfusion Injury in Rats

Author(s): Bassant M.M. Ibrahim, Sahar E.S. Harraz and Ahlam H.Mahmoud

Cerebral Ischaemia/reperfusion injury(I/RI)is a common cause of brain damage. The use of antioxidants has beneficial effects in I/RI, as they protect against brain damage by inhibiting reperfusion injury. The present study was conducted to investigate the role of vitamin C in the protection against cerebral I/RI, induced in rats and its effect on biomarkers of oxidative and nitrosative stress, and on markers of inflammation. Male rats were divided into six groups: The first was sham operated group, the second group was I/RI and the last four received intravenous (IV) vitamin C in doses 50 and 100mg/kg before and after I/RI. Reduced glutathione, malondialdehyde, nitric oxide, tumour necrosis factor alpha and interleukin one beta were measured in brain homogenates. Results showed that both doses of vitamin C given before and after I/RI induction had protective effect on brain tissue against I/RI


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