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Preparation, investigation, theoretical study and biological activity of 2-[4-acetyl phenoxy) N-(4-substitutent phenyl)] acetoamide derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Preparation, investigation, theoretical study and biological activity of 2-[4-acetyl phenoxy) N-(4-substitutent phenyl)] acetoamide derivatives

Author(s): Hanan A. Al-hazam*, Bushra Kamel and Afrodet A. Saleh

We have prepare a number of 2-[4-acetyl phnoxy) N-(4-substitutent phenyl)] acetoamide from reaction α-chloro acetoamide-N-(P-substitute phenyl) with p- acetyl phenol in the presence of sodium and absolute ethanol. All products, have been characterized by IR and theoretical study. The anti bacterial activity of prepared compounds was described. The in vitro anti bacterial activity of the compounds was determined against pathogenic gram negative Escherichia coli and gram positive Staphylococcus aureus bacteria. Anti bacterial results indicated that the compounds possessed a broad spectrum of activity.


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