GET THE APP

Proficient One-pot, Multi-component Synthesis of Pyrano[2,3-c]pyrazole Derivatives Using C8[DABCO]Br as Catalyst in Aqueous Medium | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Proficient One-pot, Multi-component Synthesis of Pyrano[2,3-c]pyrazole Derivatives Using C8[DABCO]Br as Catalyst in Aqueous Medium

Author(s): Imen Boualia, Sabrina Benelhadj, Abdelmadjid Debache, Raouf Boulcina

C8[DABCO]Br, an ionic liquid, was demonstrated to be a highly efficient catalyst for the synthesis of a series of pyranopyrazole derivatives via a one-pot, multi-component reaction of aldehydes, hydrazine hydrate, malononitrile, and β-ketoester in water. The catalyst was found to work extremely to give the corresponding dihydropyrano[2,3-c]pyrazoles in high yields. The salient features of this new methodology are broad substrate scope conditions, short reaction times, high yields, easy work-up process, and the absence of hazardous organic solvents.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry