Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Progress in development of HIV-1 integrase inhibitor
Author(s): Shikha Kaushik, D. D. Bhragual, Kumari Varuna, Nitin Kumar, P. K. SharmaAIDS (Acquired Immuno Deficiency Syndrome) has found to be most fatal syndrome. The main causative agent of AIDS is HIV-1 integrase. Incorporation of viral DNA into the host cell genome could be translated as the basis of life-long infection. Therefore, this biochemical event, catalyzed by the enzyme integrase, is a pivotal step in viral life cycle and thus worthy of being exploited to develop anti-HIV chemotherapy. The review presented on different categories of compounds that have been studied for the inhibition of the HIV-1 integrase to develop anti-HIV agents. The categories are Oligonucleotides, Curcumin Analogues, Polyhydroxylated Aromatic Compounds, Diketo Acid,) Caffeoyl-based Inhibitors, Hydrazides and Amides, Tetracycline, Depsides and Depsidones.
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Google Scholar citation report
Citations : 15261
Der Pharma Chemica received 15261 citations as per Google Scholar report
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