Two simple UV-Spectrophotometric methods have been developed for simultaneous determination of Propranolol hydrochloride(PRH) and Flunarizine dihydrochloride(FNZ) in capsule dosage form. Methanol was used as solvent. In Method-I (Q-absorbance absorbance ratio) involves formation of Q-absorbance equation at two wavelengths i.e. 272.8 nm (isoabsorptive point) and 253 nm (λ max of FNZ). While, in Method-II (Multicomponent Mode of Analysis) involves the measurement of absorbance at two wavelengths i.e. 289 nm, λ max of PRH and 253 nm, λ max of FNZ. In both these methods PRH and FNZ followed linearity in the concentration range of 08 - 48 μg/ml for PRH and 03 – 18 μg/mL for FNZ at their respective λ max. Both these methods were found to be accurate, precise and rugged as indicated by low values of % RSD. Both these methods were also found to be rapid and economical can successfully be applied for the routine analysis of PRH and FNZ in bulk and combined capsule dosage form.
Select your language of interest to view the total content in your interested language