GET THE APP

QSAR Studies of 4-Anilinoquinazolines with Antimalarial Activity: A Hansch Approaches | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

ilbet

süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey

Abstract

QSAR Studies of 4-Anilinoquinazolines with Antimalarial Activity: A Hansch Approaches

Author(s): Aroop K. Saha, Nitish Gupta

In the present work, we report quantitative structure–activity relationship (QSAR) analysis of series of 57 6-ureido-4-anilinoquinazolines derivatives with antimalarial activity by applying linear free energy related (LFER) approach of Hansch. Multi Linear Regression analysis is used to correlate the physicochemical properties and in vitro antimalarial activity. Two best QSAR models with 3 variables are selected on the basis of various significance statistical parameters. Among the various descriptors studied, standard Gibbs free energy (SGFE), LogP, Molecular refractivity (MR) and energy of highest occupied molecular orbital (HOMO) parameters has significance impact and show good correlation coefficients (r = 0.946 and 0.393) with antimalarial activity. The calculated F value of both models determines a confidence limit superior to 99% for this model.


PDF

rokettube brazzers

paper.io

agar io

wowcappadocia.com
cappadocia-hotels.com
balloon-rides.net

wormax io

Smok
Elektronik Sigara