QSAR study of 2,4-dioxothiazolidine antidiabetic compounds | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


QSAR study of 2,4-dioxothiazolidine antidiabetic compounds

Author(s): Chawla Amit*, Chawla Payal and Dhawan RK

A series of 2,4-thiazolidinedione derivatives were synthesized and studied for antihyperglycemic activity with QSAR study. 3-(2,4-Dimethoxyphenyl)-2-{4-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxy]-phenyl}- acrylic acid methyl ester (Thz7) was found the most active compound in this series. Antihyperglycemic activity of these synthesized derivatives was described by 5 models in which the bi-parametric model-3 containing c3 and log P was found to be the best model. Some parameters proves the effectiveness of QSAR model-3, like correlation coefficient (0.947), observed square correlation coefficient (0.896), predicted square correlation coefficient (0.872) and standard error (0.079) was lowest for this model


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry