GET THE APP

Quantitative structure structure-activity relationship (QSAR) for 2-amino-5-selenothiazole derivatives as anti-inflammatory and analgesic agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Quantitative structure structure-activity relationship (QSAR) for 2-amino-5-selenothiazole derivatives as anti-inflammatory and analgesic agents

Author(s): Yousery El-Said Sherif* and Moustafa A. Gouda

Long-term clinical usage of NSAIDs is associated with significant side effects of gastrointestinal lesions, bleeding, and nephrotoxicity. Therefore the discovery of new safer anti-inflammatory drugs represents a challenging goal for such a research area. The purpose of developing a QSAR model is to reduce the cost of the target designing by modifying the molecular structures for achieving the desired molecule with the proposed property, without experimental measurement. In the current study, we extend a published work that had been investigated the selenothiazole derivatives as anti-inflammatory activity and analgesic agents. In this report, One equation was predicted using quantitative structure activity relationship (QSAR) and regression analysis for the antiinflammatory activity with a regression correlation (R) close to unity(R2~0.97, R adj.>0.84). One technique was used to investigate the validity of this equation and collagen adjuvant arthritis model in rats (in vivo).. In the pain scoring, a compound 14 was found to be more effective than Meloxicam.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry