Long-term clinical usage of NSAIDs is associated with significant side effects of gastrointestinal lesions, bleeding, and nephrotoxicity. Therefore the discovery of new safer anti-inflammatory drugs represents a challenging goal for such a research area. The purpose of developing a QSAR model is to reduce the cost of the target designing by modifying the molecular structures for achieving the desired molecule with the proposed property, without experimental measurement. In the current study, we extend a published work that had been investigated the selenothiazole derivatives as anti-inflammatory activity and analgesic agents. In this report, One equation was predicted using quantitative structure activity relationship (QSAR) and regression analysis for the antiinflammatory activity with a regression correlation (R) close to unity(R2~0.97, R adj.>0.84). One technique was used to investigate the validity of this equation and collagen adjuvant arthritis model in rats (in vivo).. In the pain scoring, a compound 14 was found to be more effective than Meloxicam.
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