GET THE APP

Quaternized Chitosan Quinoline Derivative with Potential Antibacterial Activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Quaternized Chitosan Quinoline Derivative with Potential Antibacterial Activity

Author(s): Vishalakshi B, Anush SM, Gangadhar Babaladimath

In this work, a quaternized chitosan derivative has been made by reacting chitosan with 2-hydroxy quinoline-3-carbaldehyde in presence of acetic acid to form a Schiff base intermediate, followed by reaction with sodium borohydride and methyl iodide to obtain the water soluble quaternized product. The heterocylclically modified quaternized compound was characterized by Fourier Transform Infra-Red (FTIR), X-rey Diffraction (XRD), Thermogravimetric Analysis (TGA) and UV-Visible spectroscopy. The antimicrobial activity of the quaternized product was investigated against Gram-positive and Gram-negative bacteria using agar well diffusion method. The results showed that the modified compound showed good inhibitory action attributed to the presence of hydrophobic quinoline moiety.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 15261

Der Pharma Chemica received 15261 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry