Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Rapid, Economical and Green Solid Oxidation of Sulfides to Sulfones and Their Antimicrobial Evaluation- Part 2

Author(s): Anil M. Manikrao, Dinesh R. Chaple, Niranjan S. Mahajan, Prafull M. Sabale

The sulfones (IIa-k) of various 3-(N-substituted carboxamidoethylthio)-(4H)-1, 2, 4-triazoles (Ia-k) were synthesized by highly selective oxidation method using oxone®. Through this solid state “Green” oxidation technique, the titled compounds were obtained in good purity and high yields. The structures of the synthesized compounds were confirmed using IR, 1H-NMR spectra and elemental analysis. All the compounds were screened for their antibacterial and antifungal activities. Almost all the compounds showed comparable antibacterial and antifungal activities with that of standards, but none of them found to possess promising these activities. The oxidation system was found clean, safe, operationally simple, and environmentally friendly method. Thus it meets the needs of contemporary “Green Chemistry” and found suitable for practical synthesis.


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