Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Rapid, economical and green solid oxidation of sulfides to sulfoxides and their antimicrobial evaluation- part 1

Author(s): Anil M. Manikrao, Harish K. Kunjwani, Shrinivas D. Joshi, Niranjan S. Mahajan

A “green” highly sensitive oxidation of organic sulfides, 3-(N-substituted carboxamido - ethylthio)-(4H)-1, 2, 4-triazoles (I a-k) to the corresponding sulfoxides (II a-k) was developed employing solid-state condition by using oxone®. The synthesized compounds were confirmed using elemental analysis and spectral data. These compounds were tested for their antibacterial and antifungal activities. None of them were found to possess any promising activity. This oxidation system is found clean, safe and operationally simple, environmentally friendly and meets the needs of contemporary “green chemistry”.


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